Inaugural talk - Routing and processing of sensory in cortical layers
The brain processes information in a highly distributed, parallel manner in three-dimensional space. At the neuronal population level, information is processed in spatially separate clusters of neurons. In the neocortex, these clusters appear to be organised into microcircuits distributed over six anatomically distinct layers. Precisely how neural activity in these different layers enables information processing remains a key question in neuroscience. Here, we combine electrophysiology, optogenetics and novel methods for spatiotemporally multiplexed 2-photon imaging to address this question. We dissociate the role different types of local inhibition play in layer-specific routing and processing of packets of sensory information and explore layer-specific changes in neural activity during learning. Overall, our data points at fundamental principles underlying cortical layer-specific processing that are likely shared between cortical areas.