High-resolution synaptic imaging in health and disease
Synapse loss is an early feature of many neurodegenerative disorders and is the strongest correlate with cognitive decline in Alzheimer’s disease. Electron microscopy has been the gold standard approach for examining synaptic structure and density, however it is a laborious technique and new high-throughput approaches are required. In Edinburgh, we use the high-resolution technique array tomography to analyse synaptic density and protein composition in human post-mortem tissue and animal models. This talk will introduce the technique and summarise some of the projects underway in the lab, ranging from healthy brain ageing in the Lothian Birth Cohort 1936 to pathological protein aggregation in animal models of Alzheimer’s disease.